Ibrutinib versus Ofatumumab in Previously Treated Chronic Lymphoid Leukemia
Identifieur interne : 004117 ( Main/Exploration ); précédent : 004116; suivant : 004118Ibrutinib versus Ofatumumab in Previously Treated Chronic Lymphoid Leukemia
Auteurs : J. C. Byrd [États-Unis] ; J. R. Brown [États-Unis] ; S. O'Brien [États-Unis] ; J. C. Barrientos [États-Unis] ; N. E. Kay [États-Unis] ; N. M. Reddy [États-Unis] ; S. Coutre [États-Unis] ; C. S. Tam [Australie] ; S. P. Mulligan [Australie] ; U. Jaeger [Autriche] ; S. Devereux [Royaume-Uni] ; P. M. Barr [États-Unis] ; R. R. Furman [États-Unis] ; T. J. Kipps [États-Unis] ; F. Cymbalista [États-Unis] ; C. Pocock [Royaume-Uni] ; P. Thornton [Irlande (pays)] ; F. Caligaris-Cappio [Italie] ; T. Robak ; J. Delgado ; S. J. Schuster ; M. Montillo ; A. Schuh [Royaume-Uni] ; S. De Vos [États-Unis] ; D. Gill [Australie] ; A. Bloor [Royaume-Uni] ; C. Dearden [Royaume-Uni] ; C. Moreno ; J. J. Jones [États-Unis] ; A. D. Chu [États-Unis] ; M. Fardis [États-Unis] ; J. Mcgreivy [États-Unis] ; F. Clow [France] ; D. F. James [États-Unis] ; P. Hillmen [Royaume-Uni]Source :
- The New England journal of medicine [ 0028-4793 ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Médecine.
English descriptors
- KwdEn :
Abstract
BACKGROUND In patients with chronic lymphoid leukemia (CLL) or small lymphocytic lymphoma (SLL), a short duration of response to therapy or adverse cytogenetic abnormalities are associated with a poor outcome. We evaluated the efficacy of ibrutinib, a covalent inhibitor of Bruton's tyrosine kinase, in patients at risk for a poor outcome. METHODS In this multicenter, open-label, phase 3 study, we randomly assigned 391 patients with relapsed or refractory CLL or SLL to receive daily ibrutinib or the anti-CD20 antibody ofatumumab. The primary end point was the duration of progression-free survival, with the duration of overall survival and the overall response rate as secondary end points. RESULTS At a median follow-up of 9.4 months, ibrutinib significantly improved progression-free survival; the median duration was not reached in the ibrutinib group (with a rate of progression-free survival of 88% at 6 months), as compared with a median of 8.1 months in the ofatumumab group (hazard ratio for progression or death in the ibrutinib group, 0.22; P<0.001). Ibrutinib also significantly improved overall survival (hazard ratio for death, 0.43; P=0.005). At 12 months, the overall survival rate was 90% in the ibrutinib group and 81% in the ofatumumab group. The overall response rate was significantly higher in the ibrutinib group than in the ofatumumab group (42.6% vs. 4.1%, P<0.001). An additional 20% of ibrutinib-treated patients had a partial response with lymphocytosis. Similar effects were observed regardless of whether patients had a chromosome 17p13.1 deletion or resistance to purine analogues. The most frequent nonhematologic adverse events were diarrhea, fatigue, pyrexia, and nausea in the ibrutinib group and fatigue, infusion-related reactions, and cough in the ofatumumab group. CONCLUSIONS Ibrutinib, as compared with ofatumumab, significantly improved progression-free survival, overall survival, and response rate among patients with previously treated CLL or SLL.
Affiliations:
- Australie, Autriche, France, Irlande (pays), Italie, Royaume-Uni, États-Unis
- Angleterre, Californie, Grand Londres, Grand Manchester, Lombardie, Oxfordshire, Vienne (Autriche), État de New York, Île-de-France
- Londres, Manchester, Milan, Oxford, Paris, Vienne (Autriche)
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000304
- to stream PascalFrancis, to step Curation: 005B58
- to stream PascalFrancis, to step Checkpoint: 000255
- to stream Main, to step Merge: 004179
- to stream Main, to step Curation: 004117
Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Ibrutinib versus Ofatumumab in Previously Treated Chronic Lymphoid Leukemia</title>
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<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Dana-Farber Cancer Institute</s1>
<s2>Boston, New York</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="O Brien, S" sort="O Brien, S" uniqKey="O Brien S" first="S." last="O'Brien">S. O'Brien</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>M.D. Anderson Cancer Center</s1>
<s2>Houston, New York</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Barrientos, J C" sort="Barrientos, J C" uniqKey="Barrientos J" first="J. C." last="Barrientos">J. C. Barrientos</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Hofstra North Shore-LIJ School of Medicine</s1>
<s2>Hempstead, New York</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kay, N E" sort="Kay, N E" uniqKey="Kay N" first="N. E." last="Kay">N. E. Kay</name>
<affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Mayo Clinic, Rochester</s1>
<s2>MN, California</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reddy, N M" sort="Reddy, N M" uniqKey="Reddy N" first="N. M." last="Reddy">N. M. Reddy</name>
<affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Vanderbilt-Ingram Cancer Center</s1>
<s2>Nashville, California</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Coutre, S" sort="Coutre, S" uniqKey="Coutre S" first="S." last="Coutre">S. Coutre</name>
<affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Stanford University School of Medicine and Stanford Cancer Institute</s1>
<s2>Stanford, California</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tam, C S" sort="Tam, C S" uniqKey="Tam C" first="C. S." last="Tam">C. S. Tam</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Peter MacCallum Cancer Centre and St. Vincent's Hospital</s1>
<s2>Melbourne, VIC</s2>
<s3>AUS</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Peter MacCallum Cancer Centre and St. Vincent's Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mulligan, S P" sort="Mulligan, S P" uniqKey="Mulligan S" first="S. P." last="Mulligan">S. P. Mulligan</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Royal North Shore Hospital</s1>
<s2>Sydney, NSW</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Royal North Shore Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jaeger, U" sort="Jaeger, U" uniqKey="Jaeger U" first="U." last="Jaeger">U. Jaeger</name>
<affiliation wicri:level="3"><inist:fA14 i1="16"><s1>Medical University of Vienna</s1>
<s2>Vienna</s2>
<s3>AUT</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Devereux, S" sort="Devereux, S" uniqKey="Devereux S" first="S." last="Devereux">S. Devereux</name>
<affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Kings College Hospital, National Health Service (NHS) Foundation Trust Denmark Hill</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Barr, P M" sort="Barr, P M" uniqKey="Barr P" first="P. M." last="Barr">P. M. Barr</name>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>University of Rochester Cancer Center</s1>
<s2>Rochester, New York</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Furman, R R" sort="Furman, R R" uniqKey="Furman R" first="R. R." last="Furman">R. R. Furman</name>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>New York-Presbyterian Hospital and Weill Cornell Medical College</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kipps, T J" sort="Kipps, T J" uniqKey="Kipps T" first="T. J." last="Kipps">T. J. Kipps</name>
<affiliation wicri:level="2"><inist:fA14 i1="10"><s1>Moores UCSD Cancer Center</s1>
<s2>San Diego, California</s2>
<s3>USA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cymbalista, F" sort="Cymbalista, F" uniqKey="Cymbalista F" first="F." last="Cymbalista">F. Cymbalista</name>
<affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Pharmacyclics</s1>
<s2>Sunnyvale, California</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
<sZ>30 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pocock, C" sort="Pocock, C" uniqKey="Pocock C" first="C." last="Pocock">C. Pocock</name>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>East Kent Hospitals</s1>
<s2>Canterbury</s2>
<s3>GBR</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>East Kent Hospitals</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thornton, P" sort="Thornton, P" uniqKey="Thornton P" first="P." last="Thornton">P. Thornton</name>
<affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Beaumont Hospital</s1>
<s2>Dublin</s2>
<s3>IRL</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Irlande (pays)</country>
<wicri:noRegion>Beaumont Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Caligaris Cappio, F" sort="Caligaris Cappio, F" uniqKey="Caligaris Cappio F" first="F." last="Caligaris-Cappio">F. Caligaris-Cappio</name>
<affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Universita Vita-Salute San Raffaele</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Robak, T" sort="Robak, T" uniqKey="Robak T" first="T." last="Robak">T. Robak</name>
</author>
<author><name sortKey="Delgado, J" sort="Delgado, J" uniqKey="Delgado J" first="J." last="Delgado">J. Delgado</name>
</author>
<author><name sortKey="Schuster, S J" sort="Schuster, S J" uniqKey="Schuster S" first="S. J." last="Schuster">S. J. Schuster</name>
</author>
<author><name sortKey="Montillo, M" sort="Montillo, M" uniqKey="Montillo M" first="M." last="Montillo">M. Montillo</name>
</author>
<author><name sortKey="Schuh, A" sort="Schuh, A" uniqKey="Schuh A" first="A." last="Schuh">A. Schuh</name>
<affiliation wicri:level="3"><inist:fA14 i1="19"><s1>Oxford Biomedical Research Centre</s1>
<s2>Oxford</s2>
<s3>GBR</s3>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Vos, S" sort="De Vos, S" uniqKey="De Vos S" first="S." last="De Vos">S. De Vos</name>
<affiliation wicri:level="2"><inist:fA14 i1="11"><s1>David Geffen School of Medicine at UCLA</s1>
<s2>Los Angeles, California</s2>
<s3>USA</s3>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gill, D" sort="Gill, D" uniqKey="Gill D" first="D." last="Gill">D. Gill</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Princess Alexandra Hospital</s1>
<s2>Brisbane, QLD</s2>
<s3>AUS</s3>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Princess Alexandra Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bloor, A" sort="Bloor, A" uniqKey="Bloor A" first="A." last="Bloor">A. Bloor</name>
<affiliation wicri:level="3"><inist:fA14 i1="20"><s1>Christie NHS Foundation Trust Hematology and Transplant Unit</s1>
<s2>Manchester</s2>
<s3>GBR</s3>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dearden, C" sort="Dearden, C" uniqKey="Dearden C" first="C." last="Dearden">C. Dearden</name>
<affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Royal Marsden Hospital and the Institute of Cancer Research</s1>
<s2>Sutton</s2>
<s3>GBR</s3>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Royal Marsden Hospital and the Institute of Cancer Research</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moreno, C" sort="Moreno, C" uniqKey="Moreno C" first="C." last="Moreno">C. Moreno</name>
</author>
<author><name sortKey="Jones, J J" sort="Jones, J J" uniqKey="Jones J" first="J. J." last="Jones">J. J. Jones</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Ohio State University Comprehensive Cancer Center</s1>
<s2>Columbus, New York</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chu, A D" sort="Chu, A D" uniqKey="Chu A" first="A. D." last="Chu">A. D. Chu</name>
<affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Pharmacyclics</s1>
<s2>Sunnyvale, California</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
<sZ>30 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fardis, M" sort="Fardis, M" uniqKey="Fardis M" first="M." last="Fardis">M. Fardis</name>
<affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Pharmacyclics</s1>
<s2>Sunnyvale, California</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
<sZ>30 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcgreivy, J" sort="Mcgreivy, J" uniqKey="Mcgreivy J" first="J." last="Mcgreivy">J. Mcgreivy</name>
<affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Pharmacyclics</s1>
<s2>Sunnyvale, California</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
<sZ>30 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clow, F" sort="Clow, F" uniqKey="Clow F" first="F." last="Clow">F. Clow</name>
<affiliation wicri:level="3"><inist:fA14 i1="23"><s1>Hôpital Avicenne</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="James, D F" sort="James, D F" uniqKey="James D" first="D. F." last="James">D. F. James</name>
<affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Pharmacyclics</s1>
<s2>Sunnyvale, California</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
<sZ>30 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hillmen, P" sort="Hillmen, P" uniqKey="Hillmen P" first="P." last="Hillmen">P. Hillmen</name>
<affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Leeds Teaching Hospitals, St. James Institute of Oncology</s1>
<s2>Leeds</s2>
<s3>GBR</s3>
<sZ>35 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">The New England journal of medicine</title>
<title level="j" type="abbreviated">N. Engl. j. med.</title>
<idno type="ISSN">0028-4793</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The New England journal of medicine</title>
<title level="j" type="abbreviated">N. Engl. j. med.</title>
<idno type="ISSN">0028-4793</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic agent</term>
<term>Chronic</term>
<term>Comparative study</term>
<term>Leukemia</term>
<term>Medicine</term>
<term>Ofatumumab</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Leucémie</term>
<term>Ofatumumab</term>
<term>Etude comparative</term>
<term>Traitement</term>
<term>Chronique</term>
<term>Médecine</term>
<term>Anticancéreux</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Médecine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">BACKGROUND In patients with chronic lymphoid leukemia (CLL) or small lymphocytic lymphoma (SLL), a short duration of response to therapy or adverse cytogenetic abnormalities are associated with a poor outcome. We evaluated the efficacy of ibrutinib, a covalent inhibitor of Bruton's tyrosine kinase, in patients at risk for a poor outcome. METHODS In this multicenter, open-label, phase 3 study, we randomly assigned 391 patients with relapsed or refractory CLL or SLL to receive daily ibrutinib or the anti-CD20 antibody ofatumumab. The primary end point was the duration of progression-free survival, with the duration of overall survival and the overall response rate as secondary end points. RESULTS At a median follow-up of 9.4 months, ibrutinib significantly improved progression-free survival; the median duration was not reached in the ibrutinib group (with a rate of progression-free survival of 88% at 6 months), as compared with a median of 8.1 months in the ofatumumab group (hazard ratio for progression or death in the ibrutinib group, 0.22; P<0.001). Ibrutinib also significantly improved overall survival (hazard ratio for death, 0.43; P=0.005). At 12 months, the overall survival rate was 90% in the ibrutinib group and 81% in the ofatumumab group. The overall response rate was significantly higher in the ibrutinib group than in the ofatumumab group (42.6% vs. 4.1%, P<0.001). An additional 20% of ibrutinib-treated patients had a partial response with lymphocytosis. Similar effects were observed regardless of whether patients had a chromosome 17p13.1 deletion or resistance to purine analogues. The most frequent nonhematologic adverse events were diarrhea, fatigue, pyrexia, and nausea in the ibrutinib group and fatigue, infusion-related reactions, and cough in the ofatumumab group. CONCLUSIONS Ibrutinib, as compared with ofatumumab, significantly improved progression-free survival, overall survival, and response rate among patients with previously treated CLL or SLL.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Autriche</li>
<li>France</li>
<li>Irlande (pays)</li>
<li>Italie</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Californie</li>
<li>Grand Londres</li>
<li>Grand Manchester</li>
<li>Lombardie</li>
<li>Oxfordshire</li>
<li>Vienne (Autriche)</li>
<li>État de New York</li>
<li>Île-de-France</li>
</region>
<settlement><li>Londres</li>
<li>Manchester</li>
<li>Milan</li>
<li>Oxford</li>
<li>Paris</li>
<li>Vienne (Autriche)</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Delgado, J" sort="Delgado, J" uniqKey="Delgado J" first="J." last="Delgado">J. Delgado</name>
<name sortKey="Montillo, M" sort="Montillo, M" uniqKey="Montillo M" first="M." last="Montillo">M. Montillo</name>
<name sortKey="Moreno, C" sort="Moreno, C" uniqKey="Moreno C" first="C." last="Moreno">C. Moreno</name>
<name sortKey="Robak, T" sort="Robak, T" uniqKey="Robak T" first="T." last="Robak">T. Robak</name>
<name sortKey="Schuster, S J" sort="Schuster, S J" uniqKey="Schuster S" first="S. J." last="Schuster">S. J. Schuster</name>
</noCountry>
<country name="États-Unis"><region name="État de New York"><name sortKey="Byrd, J C" sort="Byrd, J C" uniqKey="Byrd J" first="J. C." last="Byrd">J. C. Byrd</name>
</region>
<name sortKey="Barr, P M" sort="Barr, P M" uniqKey="Barr P" first="P. M." last="Barr">P. M. Barr</name>
<name sortKey="Barrientos, J C" sort="Barrientos, J C" uniqKey="Barrientos J" first="J. C." last="Barrientos">J. C. Barrientos</name>
<name sortKey="Brown, J R" sort="Brown, J R" uniqKey="Brown J" first="J. R." last="Brown">J. R. Brown</name>
<name sortKey="Chu, A D" sort="Chu, A D" uniqKey="Chu A" first="A. D." last="Chu">A. D. Chu</name>
<name sortKey="Coutre, S" sort="Coutre, S" uniqKey="Coutre S" first="S." last="Coutre">S. Coutre</name>
<name sortKey="Cymbalista, F" sort="Cymbalista, F" uniqKey="Cymbalista F" first="F." last="Cymbalista">F. Cymbalista</name>
<name sortKey="De Vos, S" sort="De Vos, S" uniqKey="De Vos S" first="S." last="De Vos">S. De Vos</name>
<name sortKey="Fardis, M" sort="Fardis, M" uniqKey="Fardis M" first="M." last="Fardis">M. Fardis</name>
<name sortKey="Furman, R R" sort="Furman, R R" uniqKey="Furman R" first="R. R." last="Furman">R. R. Furman</name>
<name sortKey="James, D F" sort="James, D F" uniqKey="James D" first="D. F." last="James">D. F. James</name>
<name sortKey="Jones, J J" sort="Jones, J J" uniqKey="Jones J" first="J. J." last="Jones">J. J. Jones</name>
<name sortKey="Kay, N E" sort="Kay, N E" uniqKey="Kay N" first="N. E." last="Kay">N. E. Kay</name>
<name sortKey="Kipps, T J" sort="Kipps, T J" uniqKey="Kipps T" first="T. J." last="Kipps">T. J. Kipps</name>
<name sortKey="Mcgreivy, J" sort="Mcgreivy, J" uniqKey="Mcgreivy J" first="J." last="Mcgreivy">J. Mcgreivy</name>
<name sortKey="O Brien, S" sort="O Brien, S" uniqKey="O Brien S" first="S." last="O'Brien">S. O'Brien</name>
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